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et al. Impaired bone resorption in cathepsin K-deficient mice is partly compensated for by enhanced osteoclastogenesis and increased expression of other proteases through an increased RANKL/OPG ratio.
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et al. Glucocorticoids suppress bone formation by attenuating osteoblast differentiation by means of the monomeric glucocorticoid receptor.
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et al. Mice lacking cathepsin K sustain bone transforming but produce bone fragility Inspite of high bone mass.
When employing Cre-loxP CRE products for gene activation or inactivation, thorough consideration of the right Management genotypes is important so as to precisely attribute phenotypic dissimilarities for the gene activation or inactivation rather then other aspects. Generally speaking, controls carrying the floxed gene but damaging for Cre are frequently applied. Nevertheless, in lots of situations it is vital to also involve controls expressing Cre but without the floxed gene. This is especially crucial for styles exactly where the Cre is knocked in to your endogenous gene locus and therefore inactivates one or more alleles with the gene (e.g. the CtsK-Cre KI model described earlier mentioned[39]). For inducible Cre expression models, it truly is significant to include controls with The same genotype to your experimental animals (e.
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